David Hibler

David Hibler is a registered patent agent in Dentons' Intellectual Property and Technology practice. His work focuses on the preparation and prosecution of US and foreign patent applications, mainly in the field of biotechnology. David has drafted and prosecuted patent applications covering a wide range of technologies, including recombinant nucleic acids and proteins, transgenic animals and methods, pharmaceutical agents, molecular diagnostics, medical and analytical devices, as well as a variety of mechanical inventions.

Prior to joining Dentons, David was a patent agent at Vinson & Elkins, LLP, a patent agent at Lexicon Pharmaceuticals, Inc., a Technology Analyst/Licensing Associate at the University of Texas Health Science Center at San Antonio, a patent agent at Williams, Morgan and Amerson, and a scientific advisor/patent agent at Arnold, White and Durkee.

David's doctoral research focused on determining structure/function relationships in the bacterial enzyme Staphylococcal nuclease using site-directed mutagenesis, and his post-doctoral research focused on determining structure/function relationships in the yeast regulatory protein GAL4 using site-directed mutagenesis.

Insights

Co-author, “Cloning and Characterization of Zona Pellucida Genes and cDNAs from a Variety of Mammalian Species: The ZPA, ZPB and ZPC Gene Families,” DNA Seq. 4:361-393, 1994
Co-author, “Nucleotide Sequence of cDNA Encoding ZP3, a Sperm-Binding Glycoprotein from Zona Pellucida of Pig Oocyte,” Biochim. Biophys. Acta 1174:211-214, 1993
Co-author, “Kinetic and Magnetic Resonance Studies of the Glutamate-43 to Serine Mutation of Staphylococcal Nuclease,” Biochemistry 28:1539-1548, 1989
Co-author, “Isotopic Labeling with 2H and 13C to Compare the Conformation of Proteins and Mutants Generated by Site-Directed Mutagenesis I,” Meth. Enzymol. 177:74-86, 1989
Co-author, “Isotopic Labeling with 2H and 13C to Compare the Conformation of Proteins and Mutants Generated by Site-Directed Mutagenesis II,” Meth. Enzymol. 177:282-292, 1989
Co-author, “Identification of Residues Involved in a Conformational Change Accompanying Substitutions for Glutamate 43 in Staphylococcal Nuclease,” Biochemistry 27:4127-4132, 1988
Co-author, “Site-Directed Mutants of Staphylococcal Nuclease. Detection and Localization by 1H NMR Spectroscopy of Conformational Changes Accompanying Substitutions for Glutamic Acid-43,” Biochemistry 26:6278-6286, 1987
Co-author, Staphylococcal Nuclease: Stereochemical and Genetic Probes of the Mechanism of the Hydrolysis Reaction. In "Mechanisms of Enzymatic Reactions: Stereochemistry", pp. 101-114 (Frey, P. A., ed., Elsevier Science Publishing Co., Inc., New York, NY, 1986)
Co-author, “The ompA Signal Peptide Directed Secretion of Staphylococcal Nuclease A by E. coli,” J. Biol. Chem. 260:2670-2674, 1985

Activities and Affiliations

Prior and Present Employment

David completed his National Institute of Health postdoctoral fellowship at the Department of Genetics, Washington University School of Medicine, and was a Contract Scientist at Genosys Biotechnologies, Inc. and a Research Scientist at Zonagen, Inc.